微卫星不稳定性
基因组不稳定性
前列腺癌
医学
DNA修复
计算生物学
个性化医疗
遗传学
基因
生物信息学
癌症
癌症研究
生物
微卫星
DNA
内科学
DNA损伤
等位基因
作者
D. Akhoundova,Felix Y. Feng,Colin C. Pritchard,Mark A. Rubin
标识
DOI:10.1016/j.path.2022.08.002
摘要
Prostate cancer (PCa) is characterized by profound genomic heterogeneity. Recent advances in personalized treatment entail an increasing need of genomic profiling. For localized PCa, gene expression assays can support clinical decisions regarding active surveillance and adjuvant treatment. In metastatic PCa, homologous recombination deficiency, microsatellite instability-high (MSI-H), and CDK12 deficiency constitute main actionable alterations. Alterations in DNA repair genes confer variable sensitivities to poly(ADP-ribose)polymerase inhibitors, and the use of genomic instability assays as predictive biomarker is still incipient. MSI can be assessed by immunohistochemistry To date there is a lack of consensus as to testing standards.
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