染色质重塑
生物
血管平滑肌
细胞生物学
表型
转录因子
表型转换
基因
血管紧张素II
重编程
下调和上调
染色质
遗传学
受体
内分泌学
平滑肌
作者
Junyi Yu,Wei Wang,Jining Yang,Ye Zhang,Xue Gong,Hao Luo,Nian Cao,Zaicheng Xu,Miao Tian,Peili Yang,Mei Qiao,Zhi Chen,Zhuxin Li,Chuanwei Li,Xudong Duan,Qing Lyu,Gao Chen,Bing Zhang,Yibin Wang,Gengze Wu
出处
期刊:Circulation Research
[Lippincott Williams & Wilkins]
日期:2022-09-22
卷期号:131 (9): 768-787
被引量:33
标识
DOI:10.1161/circresaha.122.321080
摘要
Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding RNAs was identified to produce functional polypeptides. However, the functional impact and regulatory mechanisms of long noncoding RNAs in VSMCs phenotype switching remain to be fully elucidated.
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