Incidence, Severity and Reversibility of Acute Kidney Injury after Elective Hip and Knee Arthroplasty in Patients Receiving Celecoxib Perioperatively as One of the Standard Multimodal Analgesic Protocols

Background: Acute Kidney Injury (AKI) may complicate up to 10% of primary lower-extremity total joint arthroplasties. However, none of these previous studies evaluated the duration and reversibility of AKI. Moreover, none specifically evaluated the impact of perioperative celecoxib on the incidence and severity of AKI, especially for patients with preexisting renal impairment. This study was to retrospectively review the incidence, severity and duration of AKI with short term perioperative celecoxib. We also aimed to evaluate the impact of perioperative celecoxib on the incidence and severity of AKI in patients with and without preexisting renal impairment.