免疫系统
免疫学
炎症
自身免疫
疾病
获得性免疫系统
生物
医学
内科学
作者
Kahindo P Muyayalo,Guang-Shun Gong,Kahindo Kiyonga Aimeé,Ai‐Hua Liao
标识
DOI:10.1080/14647273.2023.2262757
摘要
AbstractCoronavirus disease 2019 (COVID-19) is an infectious disease affecting multiple systems and organs, including the reproductive system. SARS-CoV-2, the virus that causes COVID-19, can damage reproductive organs through direct (angiotensin converting enzyme-2, ACE-2) and indirect mechanisms. The immune system plays an essential role in the homeostasis and function of the male and female reproductive systems. Therefore, an altered immune response related to infectious and inflammatory diseases can affect reproductive function and fertility in both males and females. This narrative review discussed the dysregulation of innate and adaptive systems induced by SARS-CoV-2 infection. We reviewed the evidence showing that this altered immune response in COVID-19 patients is the major indirect mechanism leading to adverse reproduction outcomes in these patients. We summarized studies reporting the long-term effect of SARS-CoV-2 infection on women’s reproductive function and proposed the chronic inflammation and chronic autoimmunity characterizing long COVID as potential underlying mechanisms. Further studies are needed to clarify the role of autoimmunity and chronic inflammation (long COVID) in altered female reproduction function in COVID-19.Keywords: SARS-CoV-2covid-19reproductive functionfertilityautoimmunityinflammationchronic autoimmunitychronic inflammation Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was supported by the Fundamental Research Funds for the Central Universities [2020kfyXGYJ116] and the Cultivation Plan of International Joint Research Platform of Huazhong University of Science and Technology [5001519009].
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