粒径
地奥司明
材料科学
分散性
傅里叶变换红外光谱
溶解度
扫描电子显微镜
溶解
粉末衍射
结晶度
化学工程
层状结构
无定形固体
分析化学(期刊)
色谱法
化学
有机化学
复合材料
结晶学
高分子化学
类黄酮
工程类
抗氧化剂
作者
Long Xie,Chengzhong Cai,Yi Cao,Xiaofang Li
标识
DOI:10.1016/j.jddst.2023.105118
摘要
Diosmin (DSN) is a plant-origin polyphenolic component that has attracted considerable interest for various physiological applications. Nevertheless, DSN shows high intersubject variation and poor oral absorption because of its poor solubility and permeability. This study examined the use of phytosaponins, specifically, tea saponins (TS), as novel stabilizers for optimizing and preparing diosmin nanosuspensions using top-down methods. The main formulation and process variables in particle size and polydispersity index were investigated by single-factor experiment optimization. The DSN nanocrystals were prepared and then characterized by electron microscopy, Fourier transform infrared spectroscopy (FT-IR), and powder X-ray diffraction (PXRD). Compared with conventional stabilizers, TS exhibited better stabilizing performance at low concentrations. The lyophilized powder, which had a particle size 478.4 ± 9.4 nm after redispersion, coupled with mannitol as lyoprotectant showed good redispersibility. Electron microscopy revealed that the nanocrystals had an irregular and lamellar morphology. PXRD and FT-IR spectroscopy indicated that the crystallinity of DSN was reduced during the production process. DSN nanosuspensions significantly enhanced the accelerated dissolution rate due to the amorphous status and decreasing particle size. Overall, this study presents an advantageous solution to poor solubility and offers a reasonable strategy for expanding the application range of DSN.
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