化学
伊萨丁
追加
立体化学
全合成
吲哚
模块化设计
组合化学
吲哚试验
有机化学
计算机科学
程序设计语言
作者
Ankush Banerjee,Tiffany A. Brisco,Zhen Zhang,Alexander Busse,Krissty Sumida,Morton Smith
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-20
卷期号:25 (47): 8413-8418
标识
DOI:10.1021/acs.orglett.3c03131
摘要
Total syntheses of the 5/5-spirocyclic indoline alkaloids (±)-spiroindimicins B, C, D, E, F, and G have been achieved via a modular approach. Our route features direct coupling of halogenated pyrrolemetal and isatin partners, Suzuki coupling to append the indole unit, Lewis acid-mediated spirocyclization, and divergent functionalization to give various family members. These syntheses are concise (six or seven steps from commercial materials) and highly amenable to analogue synthesis.
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