转化生长因子
肺纤维化
纤维化
癌症研究
医学
化学
内科学
心脏病学
作者
Zhihao Liu,Wei Liu,Huaiqing Wei,Ping Ye,Zhenjie Yu,Zheng Dong,Jiayu Ren,Shuping Zhang,Sijin Liu
标识
DOI:10.1016/j.jare.2025.07.057
摘要
Elevated lactate production in macrophages induced by PM2.5 inhibits the ubiquitination and degradation of TGF-β1 through the suppression of CHIP expression, thereby enhancing TGF-β1 secretion and exacerbating pulmonary fibrosis.
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