Evaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic System

HomeRadiologyVol. 310, No. 1 PreviousNext Reviews and CommentaryEditorialEvaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic SystemSven Haller , Linda Moy, Yoshimi AnzaiSven Haller , Linda Moy, Yoshimi AnzaiAuthor AffiliationsFrom the CIMC–Centre d'Imagerie Médicale de Cornavin, Place de Cornavin 18, 1201 Geneva, Switzerland (S.H.); Department of Surgical Sciences, Division of Radiology, Uppsala University, Uppsala, Sweden (S.H.); Faculty of Medicine, University of Geneva, Geneva, Switzerland (S.H.); Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China (S.H.); Faculty of Medicine, Tanta University, Tanta, Egypt (S.H.); Center for Advanced Imaging Innovation and Research, NYU Grossman School of Medicine, NYU Langone Health, New York, NY (L.M.); and Department of Radiology and Imaging Sciences and Department of Neurosurgery University of Utah, Salt Lake City, Utah (Y.A.).Address correspondence to S.H. (email: [email protected]).Sven Haller Linda MoyYoshimi AnzaiPublished Online:Jan 30 2024https://doi.org/10.1148/radiol.232899MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In References1. Hajdu SI. A note from history: discovery of the cerebrospinal fluid. Ann Clin Lab Sci 2003;33(3):334–336. Medline, Google Scholar2. Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 2012;4(147):147ra111. Crossref, Medline, Google Scholar3. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol 2018;17(11):1016–1024. Crossref, Medline, Google Scholar4. Taoka T, Masutani Y, Kawai H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Jpn J Radiol 2017;35(4):172–178. Crossref, Medline, Google Scholar5. Yokota H, Vijayasarathi A, Cekic M, et al. Diagnostic Performance of Glymphatic System Evaluation Using Diffusion Tensor Imaging in Idiopathic Normal Pressure Hydrocephalus and Mimickers. Curr Gerontol Geriatr Res 2019;2019:5675014. Crossref, Medline, Google Scholar6. Toh CH, Siow TY. Glymphatic Dysfunction in Patients With Ischemic Stroke. Front Aging Neurosci 2021;13:756249. Crossref, Medline, Google Scholar7. Zhang W, Zhou Y, Wang J, et al. Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage 2021;238:118257. Crossref, Medline, Google Scholar8. Taoka T, Ito R, Nakamichi R, et al. Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study. Jpn J Radiol 2022;40(2):147–158. Crossref, Medline, Google Scholar9. Klostranec JM, Vucevic D, Bhatia KD, et al. Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part I-Anatomy and Physiology. Radiology 2021;301(3):502–514. Link, Google Scholar10. Klostranec JM, Vucevic D, Bhatia KD, et al. Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part II-Imaging Techniques and Clinical Applications. Radiology 2021;301(3):516–532. Link, Google ScholarArticle HistoryReceived: Oct 25 2023Revision requested: Oct 25 2023Revision received: Nov 1 2023Accepted: Nov 1 2023Published online: Jan 30 2024 FiguresReferencesRelatedDetailsRecommended Articles Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part II—Imaging Techniques and Clinical ApplicationsRadiology2021Volume: 301Issue: 3pp. 516-532Altered Brain Glymphatic Flow at Diffusion-Tensor MRI in Rapid Eye Movement Sleep Behavior DisorderRadiology2023Volume: 307Issue: 5Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical PracticeRadiology2023Volume: 307Issue: 5Safety of Intrathecal Administration of Gadolinium-based Contrast Agents: A Systematic Review and Meta-AnalysisRadiology2020Volume: 297Issue: 1pp. 75-83Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank StudyRadiology2019Volume: 291Issue: 3pp. 763-771See More RSNA Education Exhibits What Do We Know About Emerging Methods for Imaging The Glymphatic System?Digital Posters2022CSF Circulation and Glymphatic System of the Spinal CordDigital Posters2022Decoding White Matter Tracts in Brain : Role of Diffusion Tensor Imaging (DTI) and Tractography in Brain TumorsDigital Posters2022 RSNA Case Collection Callosal agenesis and interhemispheric cystRSNA Case Collection2020Normal Pressure HydrocephalusRSNA Case Collection2021Childhood X linked AdrenoleukodystrophyRSNA Case Collection2020 Vol. 310, No. 1 Metrics Altmetric Score PDF download