Machine learning insights into the antioxidant and biomolecular shielding effects of polyphenol-rich 18 date palm pit extracts

/100 g). Enzyme inhibition varied widely: Maghool inhibited tyrosinase by 65.40 %, while Shabebe showed 42.21 % α-amylase inhibition. Protective effects against DNA and BSA damage were pronounced in Sagay (39.99 % supercoiled DNA retention) and Jabri (98.95 % BSA protection). An XGBoost model predicted antioxidant, enzyme inhibitory, and protective activities with up to 92.57 % accuracy, identifying catechin and cinnamic acid as key predictors. These findings underscore the potential of date pits as sustainable sources of bioactive compounds for nutraceutical and pharmaceutical applications.