A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotides

The study on polynucleotide efficacy in skin rejuvenation, alongside the review of regulatory status and guidelines within the UK, delineates a progressive outlook on this emerging therapeutic modality in aesthetic medicine. Polynucleotides have demonstrated notable efficacy in enhancing skin hydration, elasticity, and overall dermal health, primarily through mechanisms that promote cellular repair and collagen synthesis. This systematic review synthesises findings from various clinical studies to elucidate the significant therapeutic potentials of polynucleotides, revealing their capacity to improve skin texture and integrity, which are critical in the aesthetic rejuvenation of aging skin. Further, the review highlights a critical gap in the regulatory framework governing the use of polynucleotides within the United Kingdom.