Agarose Hydrogels for Bone Tissue Engineering, from Injectables to Bioprinting

A great interest in agarose, with many health-promoting and gel properties, has been registered, especially in the field of bone regeneration and repair. Agarose and its major bioactive compounds are involved in biological activities such as inflammation, cell adhesion and proliferation, and the promotion of tissue repair. Due to its unique physical properties like gelation and solubility, agarose is increasingly utilized in the medical industry. The aim of this review is to present an overview of the applications of agarose hydrogels in bone tissue engineering, introducing agarose and its modified products as innovative solutions for bone regeneration. Additionally, the injectability of agarose hydrogels and their applications in bioprinting are also summarized. Data indicate that agarose will play an increasing role in current and future global medical sectors.