医学
转移性尿路上皮癌
肿瘤科
荟萃分析
内科学
养生
人口
尿路上皮癌
癌症
化疗
免疫疗法
膀胱癌
环境卫生
作者
Matteo Ferro,Felice Crocetto,Octavian Sabin Tătaru,Biagio Barone,Pasquale Dolce,Giuseppe Lucarelli,Guru Sonpavde,Gennaro Musi,Alessandro Antonelli,Alessandro Veccia,Daniela Terracciano,Gian Maria Busetto,Francesco Del Giudice,Michele Marchioni,Michele Marchioni,Francesco Porpiglia,Cristian Fiori,Giuseppe Carrieri,Francesco Lasorsa,Antonio Verde,Luca Scafuri,Carlo Buonerba,Giuseppe Di Lorenzo
标识
DOI:10.1016/j.clgc.2023.05.017
摘要
Several programmed death ligand-1 (PD1/L1) immune checkpoint inhibitors (ICIs) are approved in urothelial carcinoma (UC).To address the need for predictors of the efficacy of ICIs in metastatic urothelial carcinoma (mUC), randomized controlled trials of PD1/L1 inhibitors alone or in combination with chemotherapy in this patient population were systematically reviewed, and differences in ICI-associated survival outcomes according to available baseline variables were quantitatively assessed.The quantitative analysis included 6524 patients with mUC. No visceral metastatic site (HR 0.67; 95% CI, 0.76-0.90) and high PDL-1 expression (HR 0.74; 95% CI, 0.640.87) were significantly associated with a reduced risk of death.Treatment with an ICI-containing regimen was associated with a reduced risk of death in mUC patients, which was associated with PDL-1 expression and metastatic site. Further research is warranted.
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