MDMX公司
平方毫米
生物
抑制器
背景(考古学)
抄写(语言学)
细胞生物学
癌症研究
转录因子
功能(生物学)
遗传学
基因
语言学
哲学
古生物学
作者
Alyssa Klein,Rafaela Muniz de Queiroz,Divya Venkatesh,Carol Prives
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2021-04-22
卷期号:35 (9-10): 575-601
被引量:58
标识
DOI:10.1101/gad.347872.120
摘要
Most well studied as proteins that restrain the p53 tumor suppressor protein, MDM2 and MDMX have rich lives outside of their relationship to p53. There is much to learn about how these two proteins are regulated and how they can function in cells that lack p53. Regulation of MDM2 and MDMX, which takes place at the level of transcription, post-transcription, and protein modification, can be very intricate and is context-dependent. Equally complex are the myriad roles that these two proteins play in cells that lack wild-type p53; while many of these independent outcomes are consistent with oncogenic transformation, in some settings their functions could also be tumor suppressive. Since numerous small molecules that affect MDM2 and MDMX have been developed for therapeutic outcomes, most if not all designed to prevent their restraint of p53, it will be essential to understand how these diverse molecules might affect the p53-independent activities of MDM2 and MDMX.
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