阿托品
化学
对映选择合成
催化作用
立体选择性
轴手性
组合化学
立体化学
纳米技术
有机化学
材料科学
作者
Jun Kee Cheng,Shao‐Hua Xiang,Shaoyu Li,Ye Liu,Bin Tan
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-03-27
卷期号:121 (8): 4805-4902
被引量:511
标识
DOI:10.1021/acs.chemrev.0c01306
摘要
Atropisomerism is a stereochemical behavior portrayed by three-dimensional molecules that bear rotationally restricted σ bond. Akin to the well-represented point-chiral molecules, atropisomerically chiral compounds are finding increasing utilities in many disciplines where molecular asymmetry is influential. This provides steady demand on atroposelective synthesis, where numerous synthetic pursuits have been rewarded with conceptually novel and streamlined methods while expanding the structural diversity of atropisomers. This review summarizes key achievements in stereoselective preparation of biaryl, heterobiaryl, and nonbiaryl atropisomers documented between 2015 and 2020. Emphasis is placed on the synthetic strategies for each structural class, while examples are cited to illustrate the potential applications of the accessed atropochiral targets.
科研通智能强力驱动
Strongly Powered by AbleSci AI