生物
Wnt信号通路
胎盘
串扰
滋养层
细胞
胎儿
电池类型
细胞生物学
遗传学
信号转导
怀孕
光学
物理
作者
Xiaobo Zhou,Yingchun Xu,Shengnan Ren,Dong Liu,Ningjie Yang,Qian Han,Shuangbo Kong,Haibin Wang,Wenbo Deng,Hongbo Qi,Jinhua Lu
标识
DOI:10.1016/j.yexcr.2021.112715
摘要
The mammalian placenta consists of a set of cells to ensure normal placental functions throughout gestation. Dysfunctional placentae are considered as the origin of a series of pregnancy complications. Therefore, it is urgent for detailed information about the molecular recipes of the cell types within the normal placenta. In the past years, gene expression analysis via single-cell RNA-seq (scRNA-seq) offers opportunities to identify new cell types in a variety of organs and tissues. In this study, scRNA-seq was used to explore the cell heterogeneity within the E10.5 mouse placenta and unravel their discrepancies in cell composition and communications. We identified sixteen cell clusters, including some cell clusters that originated from the maternal tissue. Moreover, we traced the developmental trajectories of trophoblasts and Hofbauer-like cells. Further analysis revealed cell connections between the endothelial cells and pericytes, syncytiotrophoblasts, as well as decidual cells. Besides, we highlighted several signaling pathways, such as the EGF, FGF, canonical, and non-canonical WNT signaling pathways, which mediated the potential crosstalk between different cell types within placenta. Our research provides an in-depth understanding of placental development, cellular composition, and communications at the maternal-fetal interface.
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