皮克林乳液
稳定器
光热治疗
材料科学
生物相容性
纳米技术
生物相容性材料
乳状液
光热效应
化学工程
纳米颗粒
生物医学工程
工程类
冶金
作者
Shahinur Acter,Mark Louis P. Vidallon,Joshua P. King,Boon Mian Teo,Rico F. Tabor
摘要
Pickering emulsions with stimuli responsive properties have attracted mounting research attention owing to their potential for on-demand destabilisation of emulsions. However, a combination of biocompatibility and long-term stability are essential to efficiently apply such systems in biomedical applications, and this remains a significant challenge. To address current limitations, here we report the formation of photothermally responsive oil-in-water (o/w) Pickering emulsions fabricated using biocompatible stabilisers and showing prolonged stability. For the first time, we explore polydopamine (PDA) bowl-shaped mesoporous nanoparticles (PDA nanobowls) as a Pickering stabiliser without any surface modification or other stabiliser present. As-prepared PDA nanobowl-stabilised Pickering emulsions are shown to be pH responsive, and more significantly show high photothermal efficiency under near-infrared illumination due the incorporation of PDA into the system, which has remarkable photothermal response. These biocompatible, photothermally responsive o/w Pickering emulsion systems show potential in controlled drug release applications stimulated by NIR illumination.
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