废止
达布科
化学
催化作用
酰化
芳基
异氰酸酯
有机化学
有机催化
药物化学
立体化学
聚氨酯
对映选择合成
烷基
作者
Wei Cai,Yiming Zhou,Yanlin He,You Huang
摘要
A highly concise method for 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed [4+2] annulations of o-amino-acylation of aryl MBH carbonates with isocyanates has been developed. For the first time, MBH carbonates served as 1,4-dipoles, providing functionalized 3,4-dihydroquinazolinones in mild conditions with good to excellent yields. The density functional theory calculations of the mechanism supports our hypothesis.
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