医学
霉酚酸酯
多神经根神经病
多发性硬化
多发性肌炎
多灶性运动神经病
佐剂
药品
临床试验
皮肤病科
内科学
药理学
免疫学
格林-巴利综合征
移植
脑电图
精神科
失配负性
作者
Patrick Vermersch,Tanya Stojkovic,J. de Seze
出处
期刊:Lupus
[SAGE]
日期:2005-03-01
卷期号:14 (3_suppl): 42-45
被引量:19
标识
DOI:10.1191/0961203305lu2117oa
摘要
We describe experience with the use of mycophenolate mofetil (MMF) in neurological diseases. Although only small series of patients or case reports were described, MMF is promising in immunemediated neuromuscular disorders. MMF has been used for the treatment of polymyositis, chronic inflammatory demyelinating polyradiculoneuropathy, and multifocal motor neuropathy. These studies showed that MMF is well tolerated and may be useful in some patients. MMF can be effective alone but mainly as an adjuvant therapy by reducing steroid requirements or the frequency of infusions of IVIg. MMF has also been tested alone as a single drug treatment or in combination with immunomodulatory drugs in multiple sclerosis in open surveillance trials or in phase II studies. None of these studies have been designed to demonstrate a clinical efficacy but preliminary results are very promising.
科研通智能强力驱动
Strongly Powered by AbleSci AI