颗粒酶
穿孔素
细胞毒性T细胞
癌症研究
生物
颗粒酶B
细胞生物学
癌细胞
转化生长因子
CTL公司*
癌症免疫疗法
免疫系统
CD8型
免疫学
癌症
肿瘤微环境
免疫疗法
遗传学
体外
出处
期刊:Cancer Cell
[Elsevier]
日期:2005-11-01
卷期号:8 (5): 349-350
被引量:68
标识
DOI:10.1016/j.ccr.2005.10.018
摘要
Summary
When a cancer escapes the growth-inhibitory effects of TGF-β secreted by cancer cells themselves or by cells in the local stroma, a further adverse outcome for the host is the associated TGF-β-induced suppression of anticancer T cell immunity. In addition to the previously described dampening of T cell activation and proliferation, TGF-β markedly and directly suppresses the transcription of genes encoding multiple key proteins of the "cytotoxic program" of CD8+ CTL, such as perforin and granzymes, cytotoxins that act through the granule exocytosis pathway. The findings described below suggest that TGF-β and its signaling pathways will be major targets for novel cancer therapeutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI