ATP合酶
氧化磷酸化
细胞色素c氧化酶
三磷酸腺苷
线粒体
化学渗透
生物化学
化学
电子传输链
电化学梯度
酶
ATP合成酶γ亚单位
磷酸化
生物物理学
生物
膜
ATP酶
ATP水解
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1999-03-05
卷期号:283 (5407): 1488-1493
被引量:1178
标识
DOI:10.1126/science.283.5407.1488
摘要
Mitochondria produce most of the energy in animal cells by a process called oxidative phosphorylation. Electrons are passed along a series of respiratory enzyme complexes located in the inner mitochondrial membrane, and the energy released by this electron transfer is used to pump protons across the membrane. The resultant electrochemical gradient enables another complex, adenosine 5′-triphosphate (ATP) synthase, to synthesize the energy carrier ATP. Important new mechanistic insights into oxidative phosphorylation have emerged from recent three-dimensional structural analyses of ATP synthase and two of the respiratory enzyme complexes, cytochrome bc 1 and cytochrome c oxidase. This work, and new enzymological studies of ATP synthase's unusual catalytic mechanism, are reviewed here.
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