毒力
分泌物
微生物学
荧光素酶
致病菌
三型分泌系统
细胞内
细菌
病菌
细胞生物学
假结核耶尔森菌
生物
基因表达
调节器
小肠结肠炎耶尔森菌
细胞
转录因子
抄写(语言学)
毒力因子
基因
转染
遗传学
生物化学
哲学
语言学
作者
Jonas Pettersson,Roland Nordfelth,E. E. Dubinina,Tomas Bergman,Mikael Gustafsson,Karl‐Eric Magnusson,Hans Wolf‐Watz
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-08-30
卷期号:273 (5279): 1231-1233
被引量:397
标识
DOI:10.1126/science.273.5279.1231
摘要
Upon contact with the eukaryotic cell, Yersinia pseudotuberculosis increased the rate of transcription of virulence genes (yop), as determined by in situ monitoring of light emission from individual bacteria expressing luciferase under the control of the yopE promoter. The microbe-host interaction triggered export of LcrQ, a negative regulator of Yop expression, via the Yop-type III secretion system. The intracellular concentration of LcrQ was thereby lowered, resulting in increased expression of Yops. These results suggest a key role for the type III secretion system of pathogenic bacteria to coordinate secretion with expression of virulence factors after physical contact with the target cell.
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