化学
催化作用
钯
酰胺
组合化学
有机化学
药物化学
作者
Adam A. Rosenberg,Jinbo Zhao,David Clark
出处
期刊:Organic Letters
[American Chemical Society]
日期:2012-03-13
卷期号:14 (7): 1764-1767
被引量:36
摘要
A facile synthesis of imidazo[4,5-b]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine has been demonstrated, as well as the total synthesis of the mutagen 1-Me-5-PhIP.
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