Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines

Pentafluorosulfanyl power! The SF5 group—a novel substituent with striking physicochemical properties—was used as building block for trypanothione reductase (TR) inhibitors and compared to its CF3 and C(CH3)3 relatives. The high in vitro activities of these derivatives against Trypanosoma brucei rhodesiense as well as against Plasmodium falciparum supports the suitability of SF5 as a component of drug-like compounds. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.