骨膜炎
增殖性玻璃体视网膜病变
细胞生物学
视网膜
化学
细胞粘附分子
癌症研究
粘附
视网膜脱离
医学
生物
细胞外基质
生物化学
有机化学
作者
Keijiro Ishikawa,Shigeo Yoshida,Shintaro Nakao,Takahito Nakama,Takeshi Kita,Ryo Asato,Yukio Sassa,Ryoichi Arita,Masao Miyazaki,Hiroshi Enaida,Yuji Oshima,Noboru Murakami,Hiroaki Niiro,Junya Ono,Akira Matsuda,Yoshinobu Goto,Koichi Akashi,Kenji Izuhara,Akira Kudo,Toshihiro Kono,Ali Hafezi‐Moghadam,Tatsuro Ishibashi
摘要
Proliferative vitreoretinopathy (PVR) is a severe, vision-threatening disorder characterized by the fibrous membrane formation that leads to tractional retinal detachment. There has been no effective therapeutic approach other than vitreoretinal surgery. In this study, DNA microarray analysis of the fibrous membranes revealed significant up-regulation of periostin. We also found increased periostin expression in the vitreous and retinal pigment epithelial (RPE) cells from fibrous membranes of PVR patients. In vitro, periostin increased proliferation, adhesion, migration, and collagen production in RPE cells through integrin αV-mediated FAK and AKT phosphorylation. Periostin blockade suppressed migration and adhesion induced by TGFβ2 and PVR vitreous. In vivo, periostin inhibition had the inhibitory effect on progression of experimental PVR in rabbit eyes without affecting the viability of retinal cells. These results identified periostin as a pivotal molecule for fibrous membrane formation as well as a promising therapeutic target for PVR.
科研通智能强力驱动
Strongly Powered by AbleSci AI