Natural Acetylcholinesterase Inhibitors Used in Alzheimer's Disease Treatment

Alzheimer's Disease, one of the most progressive neurodegenerative diseases, is characterized by cognitive disfunction, dementia and also lower acetylcholine levels in the learning and memory sections of the patients' brains (1,2). According to the cholinergic hypothesis, the inhibition of acetylcholinesterase enzyme (AChE) which catalyzes the acetylcholine hydrolysis, increases the acetylcholine levels in the brain and regulates the degenerative cholinergic functions (2).