自噬
缺氧(环境)
肿瘤微环境
生物
癌症研究
抗药性
细胞凋亡
DNA损伤
癌症治疗
肿瘤缺氧
癌症
生物信息学
医学
内科学
放射治疗
肿瘤细胞
DNA
化学
遗传学
氧气
有机化学
作者
Xinming Jing,Fengming Yang,Chao‐Peng Shao,Ke Wei,Mengyan Xie,Hua Shen,Yongqian Shu
标识
DOI:10.1186/s12943-019-1089-9
摘要
Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy.Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms.Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux.Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.
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