汗水
生物传感器
体积热力学
可穿戴计算机
线性范围
检出限
计算机科学
动态范围
化学
材料科学
色谱法
纳米技术
生物医学工程
嵌入式系统
物理
医学
量子力学
内科学
计算机视觉
作者
Andreu Vaquer,Enrique Barón,Roberto de la Rica
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2020-12-29
卷期号:6 (1): 130-136
被引量:43
标识
DOI:10.1021/acssensors.0c01980
摘要
In this manuscript, we introduce a wearable analytical platform that simultaneously measures the concentration of sweat lactate and sample volume. It contains two sensors entirely made of filter paper that can be easily affixed on the skin with medical-grade tape. The lactate biosensor features a unique signal modulation mechanism that enables fine-tuning the dynamic range. It consists of adding a competitive enzyme inhibitor in different reservoirs. Thanks to this, it is possible to choose between a very low limit of detection (0.06 mM) and a linear response in the physiological concentration range (10–30 mM). The sweat volume sensor was obtained by adding a reservoir containing gold nanoparticles. As the wearer sweats, the nanoparticles are carried through a paper channel. This is used to gauge the volume of sample by measuring the distance traveled by the nanoprobes. Using fine-tuned lactate biosensors and combining them with the volume sensors allowed us to quantify variations in the levels of sweat lactate independently of the wearer’s sweat rate during an exercise routine. The platform design can be customized to meet the end user’s needs, which makes it ideal for developing a wide array of disposable wearable biosensors.
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