多发性硬化
视神经脊髓炎
急性播散性脑脊髓炎
内科学
视神经炎
疾病
发病年龄
儿科
髓鞘少突胶质细胞糖蛋白
作者
Sara Mariotto,Matteo Gastaldi,Luisa Grazian,Chiara Rosa Mancinelli,Ruggero Capra,Romaine Marignier,Daniela Alberti,Serena Zanzoni,Kathrin Schanda,Diego Franciotta,Francesca Calabria,Salvatore Monaco,Markus Reindl,Sergio Ferrari,Alberto Gajofatto
标识
DOI:10.1016/j.msard.2021.102833
摘要
The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients with MOGAD to clarify the timing of axonal damage. In comparison with disease onset values (median 8.9 pg/mL, range 1.8-97), NfL levels remained stable or decreased in most follow-up measurements (n=52, median 6.7 pg/mL, range 0.2-207), including those measured on relapses. The predominant axonal damage occurs during onset, which could be the main driving factor of final disability, with subsequent relevant clinical and therapeutic implications.
科研通智能强力驱动
Strongly Powered by AbleSci AI