Bio)molecular surface patterning by phototriggered oxime ligation

Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces (see scheme) with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.