脂肪生成
受体
过氧化物酶体
G蛋白偶联受体
脂肪组织
过氧化物酶体增殖物激活受体γ
核受体
脂氧合酶
脂肪细胞
多不饱和脂肪酸
细胞生物学
功能(生物学)
脂质信号
生物化学
化学
过氧化物酶体增殖物激活受体
信号转导
生物
酶
转录因子
脂肪酸
基因
作者
Valentin Barquissau,Rayane A. Ghandour,Gérard Ailhaud,Martin Klingenspor,Dominique Langin,Ez-Zoubir Amri,Didier F. Pisani
出处
期刊:Biochimie
[Elsevier]
日期:2017-05-01
卷期号:136: 3-11
被引量:57
标识
DOI:10.1016/j.biochi.2016.12.012
摘要
Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6 polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase activities. Oxylipins are involved in the development and function of adipose tissue and their productions are strictly related to diet quality and quantity. Oxylipins signal via cell surface membrane (G Protein-coupled receptors) and nuclear receptors (peroxisome proliferator-activated receptors), two pathways playing a pivotal role in adipocyte biology. In this review, we made an attempt to cover the available knowledge about synthesis and molecular function of oxylipins known to modulate adipogenesis, adipocyte function and phenotype conversion, with a focus on their interaction with peroxisome proliferator-activated nuclear receptor family.
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