光热治疗
材料科学
体内
再生(生物学)
生物医学工程
药物输送
黑色素瘤
组织工程
纳米技术
癌症研究
医学
细胞生物学
生物
生物技术
作者
Qingqing Yu,Yiming Han,Xiaocheng Wang,Qin Chen,Dong Zhai,Zhengfang Yi,Jiang Chang,Yin Xiao,Chengtie Wu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2018-03-08
卷期号:12 (3): 2695-2707
被引量:157
标识
DOI:10.1021/acsnano.7b08928
摘要
The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor-initiated tissue defects.
科研通智能强力驱动
Strongly Powered by AbleSci AI