Palladium Supported on Mesoporous Silica/Graphene Nanohybrid as a Highly Efficient and Reusable Heterogeneous Catalyst for C−H Functionalization

Abstract Mesoporous silica/graphene (KIT‐6/G) with pendent 3‐mercaptopropyl groups has been prepared by condensation of surface silanols and (3‐mercaptopropyl)trimethoxysilane (MPTMS). Treatment of the mercaptopropylated with Pd(CH 3 CN) 2 Cl 2 gave a heterogeneous Pd‐catalyst (Pd@KIT‐6/G‐SH). The catalytic activity of the catalyst was investigated in two types of C−H functionalized for the synthesis of 2‐cyanoacetanilide and 2‐arylpyridine 1‐oxide derivatives via C−H activation. Additionally, for the study of the effect of thiol ligand, the Pd@KIT‐6/G was prepared from the treatment of Pd(CH 3 CN) 2 Cl 2 with KIT‐6/G. The catalyst has been successfully recovered and reused without loss of activity over seven cycles of reactions.