RNA编辑
生物
基因组编辑
转录组
神经科学
选择性拼接
小RNA
功能(生物学)
基因表达调控
机制(生物学)
计算生物学
核糖核酸
基因表达
基因
清脆的
基因亚型
细胞生物学
遗传学
认识论
哲学
作者
Mikaela Behm,Marie Öhman
标识
DOI:10.1016/j.tig.2015.12.005
摘要
Post-transcriptional RNA modification by adenosine to inosine (A-to-I) editing expands the functional output of many important neuronally expressed genes. The mechanism provides flexibility in the proteome by expanding the variety of isoforms, and is a requisite for neuronal function. Indeed, targets for editing include key mediators of synaptic transmission with an overall significant effect on neuronal signaling. In addition, editing influences splice-site choice and miRNA targeting capacity, and thereby regulates neuronal gene expression. Editing efficiency at most of these sites increases during neuronal differentiation and brain maturation in a spatiotemporal manner. This editing-induced dynamics in the transcriptome is essential for normal brain development, and we are only beginning to understand its role in neuronal function. In this review we discuss the impact of RNA editing in the brain, with special emphasis on the physiological consequences for neuronal development and plasticity.
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