Review: no evidence exists that paracetamol and ibuprofen differ for short term pain relief or safety in children, but ibuprofen more effectively reduces fever

Perrott DA, Piira T, Goodenough B, et al . Efficacy and safety of acetaminophen vs ibuprofen for treating children’s pain or fever: a meta-analysis. Arch Pediatr Adolesc Med 2004;158:521–6.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q What is the relative effectiveness and safety of paracetamol (acetaminophen) and ibuprofen for short term treatment of pain and fever in children? ### ![Graphic][5] Data sources: Medline, CINAHL, EMBASE/Excerpta Medica, Cochrane Library , Biological Abstracts, Biological Abstracts/RRM, Dissertation Abstracts International, Evidence-Based Medicine Reviews (EBMR) Best Evidence, EBMR Database of Abstracts of Reviews of Effectiveness, ERIC, Expanded Academic ASAP, General Science Abstracts, Health Reference Center Academic, Health Source Plus, Health Star, Oxford Pain Relief Database, PsycInfo, and Web of Science (all from inception to May 2002); bibliographies of relevant articles; websites; textbooks; and 4 key medical journals. ### ![Graphic][6] Study selection and assessment: randomised controlled trials (RCTs) of participants <18 years of age who were receiving either ibuprofen or paracetamol for fever or moderate … [1]: {openurl}?query=rft.jtitle%253DArchives%2Bof%2BPediatrics%2Band%2BAdolescent%2BMedicine%26rft.stitle%253DArch%2BPediatr%2BAdolesc%2BMed%26rft.aulast%253DPerrott%26rft.auinit1%253DD.%2BA.%26rft.volume%253D158%26rft.issue%253D6%26rft.spage%253D521%26rft.epage%253D526%26rft.atitle%253DEfficacy%2Band%2BSafety%2Bof%2BAcetaminophen%2Bvs%2BIbuprofen%2Bfor%2BTreating%2BChildren%2527s%2BPain%2Bor%2BFever%253A%2BA%2BMeta-analysis%26rft_id%253Dinfo%253Adoi%252F10.1001%252Farchpedi.158.6.521%26rft_id%253Dinfo%253Apmid%252F15184213%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/archpedi.158.6.521&link_type=DOI [3]: /lookup/external-ref?access_num=15184213&link_type=MED&atom=%2Febnurs%2F8%2F1%2F10.atom [4]: /lookup/external-ref?access_num=000221827700003&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif