Anti-proliferative Activity of D -mangostin from Mangosteen (Garcinia mangostana Linn.)

As part of ongoing research on development of standard extract from fruit hull of mangosteen (Garcinia mangostana Linn.) and application in pharmaceutical and cosmetic industry,D -mangostin was purified from the extract of mangosteen fruit hull. D -Mangostin exhibited high anti-proliferative activity against human colon cancer cells (HCT116 and HT29, at 80.0 % and 75.5 % inhibition, respectively) and human prostate cancer cell (PC3, at 78.5% inhibition). This result showed that mangosteen and D mangostin would be good candidate for therapeutic application for cancer treatment.