Drug Therapy of Migraine

Migraine is an episodic headache that is unilateral or bilateral, pulsating in quality, moderate to severe in intensity, and exacerbated by physical activity. Associated symptoms include nausea or vomiting, photophobia, and phonophobia. The disorder is classified as migraine with aura (previously called classic migraine) and migraine without aura (previously called common migraine), according to the presence or absence, respectively, of premonitory neurologic symptoms1.The pathophysiology of migraine is clearly related to disordered brain physiology, although neither the details nor the cause is known. The positive (stimulative) followed by negative (suppressive) neurologic symptoms of the aura and the slow spread . . .