S-1 joint synchronization efficacy of radiation therapy for patients with locally advanced nasopharyngeal carcinoma

OBJECTIVE:To analyze and investigate the effectiveness and safety of S-1joint concurrent radiotherapy in patients with advanced nasopharyngeal.METHODS:The 95cases of locally advanced NPC patients were selected in the hospital for the study from January 2008to January 2010.According to the simple random allocation,54cases were divided into the observation group with the treatment of S-1joint chemotherapy concurrent radiotherapy,and the other 41patients were divided into the control group with the treatment of radiotherapy alone.To observe the therapeutic effect of the two groups of patients,and the incidence of adverse reactions,the recurrences and living conditions of the patients were investigated by three-years follow-up after discharge.RESULTS:A total of 90patients can be used to evaluate curative effect and adverse reaction,and the clinical effective rate was the CR(complete remission)and PR(partial remission)patients accounting the ratio of total numbers.In observation group the clinical effective rate was 88.24% while the control group was 48.72%.The clinical efficiency was statistically significant(P0.01)between the two groups.Gastrointestinal reaction and bone marrow suppression rate of the observation group patient was 45.10%and 47.06%,while the control group was 20.51%and 17.95%,which was significantly higher than that of the control group(P were 0.013and 0.003).The gastrointestinal reaction and bone marrow suppression were gradeⅠ-Ⅱ which was tolerable for the patients.The incidence rate of oral mucosa reaction and radioactive dermatitis in observation group were both 82.35%compared with the control group's 82.05% and 84.62% respectively.P value was 0.592 and 0.503,which was not statistically significant(P were 0.592and 0.503).There was no difference in 1-year survival between observation group patient(98.04%)after treatment and control group(97.44%),Pvalue was 0.682.The relapse rate(1.96%)in observation group was significantly lower than that of the control group(15.38%)after treatment with the Pvalue of 0.024.In the second year and the third year,the survival rate of the observation group(98.04%,84.61%)was significantly better than that ot the control group(96.08%,79.49%)with the Pvalue of 0.024and 0.016respectively.The recurrence rate(3.92%,9.80%)in observation group was significantly lower than that of the control group(17.95%,25.64%)with the Pvalue of 0.039 3and 0.044respectively.CONCLUSIONS:The effect of combination S-1concurrent radiotherapy on the locally advanced NPC patients is significant and worthy of clinical application.