Research on labelling chemistry of o-Phenathroline with ~(99m)Tc, ~(188)Re and stable Re

With SnCl2 as reductant, tartrate as intermediate ligand, and with the aid of paper chromatography on three kinds of developing agents, the 99mTo, 188Re and stable rhenium labelling chemistry with regard to o-phenanthroline (Phen) have been studied. The labelling ratio of 99mTc-Phen can reach to 95%. For different pH values of media and at different labelling temperatures, the 99mTo-Phen products can be different, and they can have different paper chromatographic behavior in some developing agents. The labelling of 188Re and stable rhenium is more difficult than that of 99mTc. Even if large quantity of SnCl2 is used, the labelling ratio of 188Re-phen is singnificantly lower than 99mTo-Phen: the highest labelling ratio is only 50%.