Clinical research on acceleration of onset time of Cisatracurium in general anesthesia induction

【Objective】 To compare the onset time of co-administration of 3ED95(0.15 mg/kg) cisatracurium and different low doses of atracurium in general anesthesia induction with 3ED95 and 4ED95 cisatracurium respectively.So as to explore the clinical effect of drug combination for accelerating the onset time of cisatracurium.【Methods】 80 patients classified ASAⅠ～Ⅱ undergoing elective general anesthesia were randomly divided into 4 groups(n =20): group A received cisatracurium 0.15 mg/kg,group B received cisatracurium 0.20 mg/kg,group C received cisatracurium 0.15 mg/kg combined with atracurium 0.10 mg/kg,and group D received cisatracurium 0.15 mg/kg combined with atracurium 0.20 mg/kg.Neuromuscular block at adductor pollicis was monitored by a TOF-Watch SX accelerograph.Anesthesia was induced with midazolam 0.05 mg/kg,fentanyl 5 ug/kg,etomidate 0.3 mg/kg and the corresponding doses of muscle relaxants.Intubation was attempted after the first twitch height became less than 10% of baseline.The onset time(was from end of bolus injection to 100% twitch depression),intubation conditions and changes of MAP,HR,SPO2 were recorded.【Results】 There was no significant difference in intubation conditions,MAP,HR or SPO2 among the 4 groups.The onset time was significantly shorter in group C and D than in group A(P 0.05) but there was no significant difference between group B and A(P 0.05).【Conclusion】 Co-administration of 3ED95 cisatracurium and low doses of atracurium can accelerate the onset time without hemodynamic instability.Co-administration of two muscle relaxants is more effective than single usage of muscle relaxant.