11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido‐o‐Carborane and a Metal Chelator

Cu 2+ is closely correlated with certain types of physiological and pathological events. Therefore, the development of a noninvasive methodology for detecting Cu 2+ is important for understanding its biological role and relationship with disease. Herein, we report on the development of a Cu 2+ ‐specific 11 B NMR/MRI probe that contains a chelator unit, TriMEDA. The method is based on the rapid complete deboronation of nido ‐ o ‐carborane by Cu 2+ under physiological conditions.