Level change of serum neuron specific enolase, Nogo-a protein and myelin basic protein from patients with acute craniocerebral injury

Objective To observe the level change of serum neuron specific enolase(NSE), Nogo-A protein and myelin basic protein(MBP) from patients with acute craniocerebral injury after treatment. Methods 50 patients with acute craniocerebral injury in Xiaoshan Hospital of Traditional Chinese Medicine from January 2012 to April 2013 were selected for the case group, these patients were given the general symptomatic treatments with keeping airway unobstructed, inhaling oxygen, lowering the intracranial pressure, anti-infection, nourishing brain cells and prevention of complications, and the patients were given surgery timely if patients had the operation indication, the time of treatments was two weeks. 30 normal healthy people from medical examination center were selected for the control group. The level change of serum NSE, Nogo-A protein and MBP were observed before and after treatments. Results The levels of NSE of(17.12±6.75) μg/L, Nogo-A protein of(201.72±56.27) μg/L and MBP of(4.79±0.72) μg/L in the case group before treatment were significantly higher than those of NSE of(5.24±1.05) μg/L, Nogo-A protein of(106.54±31.19) μg/L and MBP of(1.12±0.24) μg/L in the control group, the differences were highly statistically significant(P 0.01). After treatment for two weeks, the levels of NSE of(9.12±3.07) μg/L, Nogo-A protein of(147.92±40.56) μg/L and MBP of(2.64±0.92) μg/L in the case group were significantly lower than those of NSE of(17.12±6.75) μg/L, Nogo-A protein of(201.72±56.27) μg/L and MBP of(4.79±0.72) μg/L in the case group before treatments, the differences were highly statistically significant(t = 3.08, 2.31, 2.91, P 0.05 or P 0.01). Conclusion Abnormal elevation of the levels of serum NSE, Nogo-A protein and MBP can be used as sensitivity index for early diagnosis of acute craniocerebral injury, and changes of these levels can reflect the injury degree of brain cell. The levels of serum NSE, Nogo-A protein and MBP can be used as the index for the clinical follow-up and prognosis of acute craniocerebral injury.