Effects of Xinhuang Tablets and its Chinese Medicine Components on High Uric Acid Mice Caused by Hypoxanthine

OBJECTIVE To investigate effect of Xinhuang tablets and its Chinese medicine components on high uric acid Mice Caused by hypoxanthine,and discusse its mechanism. METHODS The mice models of high uric acid caused by injecting hypoxanthine and the normal mice were adopted. After giving different doses of intragastric administration with extracts from Xinhuang tablets and its Chinese medicine components on the mice by gavage,the uric and xanthine oxidase level of each group were determined. RESULTS After 1h of intraperitoneal injection of hypoxanthine,positive control group and Xinhuang tablets and its Chinese medicine components dosage( 23. 75、47. 5、95mg·kg- 1) could against high uric mice induced by hypoxanthine and reduced the activity of xanthine oxidase in hepar( P 0. 01). CONCLUSION Xinhuang tablets and its Chinese medicine components could decrese the blood uric acid levels by inhibiting the activity of xanthine oxidase.