Objective To compare the curative effects and the adverse effects between Paroxetine and Fluoxetine.Methods According to CCMD-3,there were 60 samples from patients of depression who were stochastically group in two sets.They were treated by Paroxetine and Fluoxetine in 6 weeks with dose 20mg/d.Results The effective power of Paroxetine is 83.3%.The effective power of Fluoxetine is 76.7%.According to HAMD,the curative effects of Paroxetine are obvious in 1 week.Fluoxetine's are in 4 weeks.Paroxetine is better.Conclusion Paroxetine's adverse effects are less.Curative effects of Paroxetine are better than neotype antidepressants.