NF-κB activity in aged mouse organs

Objective The nuclear factor κB (NF κB) is a ubiquitous transcription factor in mammalian cells. It was reported that NF κB regulated the expression of genes responsible for multiple biological processes including immune responses,inflammatory reaction,cell proliferation and apoptosis. The current study was to examine changes in the expression and activity of the NF κB in the aged mouse organs in order to study the role of NF κB in ageing and multiple organ dysfunction syndrome in the elderly(MODSE). Methods The expression and activity of NF κB in aged mouse organs were examined with immunohistochemistry and electrophoretic mobility shift assay(EMSA) respectively. Results The expression and DNA binding activity of NF κB increased remarkably in organs of aged mice, especially in the lung. Conclusions NF κB may be an important transcription factor in ageing processes and MODSE.