Expression of KLF-6 protein in colorectal cancer and its correlation with serum CEA

Objective To study the expression of KLF6 protein in colorectal cancer(CRC) and its correlation with serum CEA level. Methods The expression of KLF6 protein in colorectal cancer,colorectal adenoma,and normal colorectal tissues was detected by immunohistochemistry.Serum CEA level in patients with colorectal cancer was measured by ELISA. Results The expression of KLF6 protein in normal colorectal tissues,colorectal adenoma and colorectal cancer were 85.7%,76.5% and 43.6%,respectively,with significant differences among them(X2=25.20,P0.01).KLF6 expression was significantly correlated with differentiation grade,lymph node metastasis and TNM stage(P0.05).However,no significant correlation between KLF6 expression and CEA was found(P0.05). Conclusion Reducd expression of KLF6 in CRC suggests its inhibition on the oncogenesis of colorectal cancer.KLF6 is a useful marker for cancer risk evaluation of colorectal cancer.