Experimental study on different concentrations of autologous bone marrow transplantation in the treatment of bone nonunion

Objective To investigate the therapeutic effect of different concentrations of autologous bone marrow transplantation on bone nonunion so as to provide reliable basis for treating bone nonunion in clinic.Methods 36 healthy New Zealand rabbits were selected to make bone nonunion models.All the experimental animals were randomly divided into 3 groups:group A with 1:1 marrow;group B with 1:2 marrow;group C with 1:4 marrow.The healing state of bone fracture and callus quality were evaluated by regular X-ray examination,bone densitometry and histological observation.Results At 2,4,8 weeks after the operation,the healing state of bone fracture and callus quality were improved in group A,B,C in turn.Conclusion Autologous bone marrow transplantation can enhance healing speed and quality of bone fracture.Healing speed and quality of bone fracture are positively correlated with transplanted bone marrow concentration.