Studies on antiparasitic agents: effect of the lactam nucleus substitution in the 2-position on the in-vitro activity of new 5-nitroimidazoles

The in-vitro antiprotozoal activity of a series of new 5-nitroimidazoles substituted in the 2-position via a lactam nucleus was studied. All these compounds exhibited a better effect than metronidazole and structure-activity relationships are discussed.