淋巴瘤
穿孔
血管免疫母细胞性T细胞淋巴瘤
医学
爱泼斯坦-巴尔病毒
病理
病毒
弥漫性大B细胞淋巴瘤
化疗
B细胞淋巴瘤
癌症研究
免疫学
内科学
T细胞
免疫系统
材料科学
冲孔
冶金
作者
Tsutomu Takahashi,Riruke Maruyama,Satoko Mishima,Masayasu Inoue,Keisuke Kawakami,Chie Onishi,Toru Miyake,Junko Tanaka,Toru Nabika,Hiroto Ishikura
出处
期刊:Journal of Clinical and Experimental Hematopathology
[Japanese Society for Lymphoreticular Tissue Research]
日期:2010-01-01
卷期号:50 (1): 59-63
被引量:16
摘要
On rare occasions, secondary Epstein-Barr virus (EBV)-associated B cell lymphoma can develop in a patient with angioimmunoblastic T-cell lymphoma (AITL). We report a case of a 66-year-old Japanese woman who developed diffuse large B-cell lymphoma (DLBCL) in her small intestine after chemotherapy for AITL. She was found to have panperitonitis due to perforation of the small intestine. Partial ileectomy specimen showed DLBCL cells infiltrating into the intestinal wall. In situ hybridization for EBV-encoded RNA revealed positivity in the lymphoma cells. The lymph nodes diagnosed as AITL were negative for EBV infection and there was no coexistence of B cell neoplasms in them. We thought small bowel perforation in this case was caused by EBV-associated B cell lymphoma secondary to AITL. Our case showed a remarkable deficiency of cellular immunity after chemotherapy, which we postulate was related to the cause of occurrence of B-cell lymphoma. [J Clin Exp Hematopathol 50(1) : 59-63, 2010]
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