Effects of Tobacco Smoke on Recovery After Nerve Crush Injury in Rats

In Brief The effects of tobacco smoke on nerve healing after crush injury was studied in a rat model. Thirty-six animals were randomized equally into smoke-exposed or nonsmoke-exposed groups. Two nerve crush injuries were performed on the right posterior tibial nerve of each animal at 4-week intervals to mimic a sustained or chronic nerve injury. Recovery of the two groups was assessed with walking track analysis and nerve histomorphometry. There was no difference in the rate of nerve recovery based on walking track analysis in the smoke-exposed animals compared with nonexposed animals. The study also failed to demonstrate any significant difference between the two groups as assessed by histomorphometric criteria. In a rat posterior tibial nerve double-crush model, rate of recovery was unaffected by heavy exposure to high-tar cigarette smoke four times daily for 4 weeks.