雅罗维亚
代谢工程
合成生物学
酵母
生物技术
生化工程
生物
计算生物学
毕赤酵母
克鲁维酵母
重组DNA
酿酒酵母
毕赤酵母
基因
生物化学
工程类
作者
Liqiu Su,Ge Zhang,Zhen Yao,Peixin Liang,Zhendong Dai,Qinhong Wang
标识
DOI:10.13345/j.cjb.200707
摘要
Over the past 30 years, Yarrowia lipolytica, Kluyveromyces, Pichia, Candida, Hansenula and other non-conventional yeasts have attracted wide attention because of their desirable phenotypes, such as rapid growth, capability of utilizing multiple substrates, and stress tolerance. A variety of synthetic biology tools are being developed for exploitation of their unique phenotypes, making them potential cell factories for the production of recombinant proteins and renewable bio-based chemicals. This review summarizes the gene editing tools and the metabolic engineering strategies recently developed for non-conventional yeasts. Moreover, the challenges and future perspectives for developing non-conventional yeasts into efficient cell factories for the production of useful products through metabolic engineering are discussed.
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